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One important component in measuring the quality of information systems or software is Usability. Usability refers to effectiveness, efficiency and user satisfaction. Therefore, it is very important to know the level of usability of a system. Measurement results can be used as valuable inputs to improve information systems or software in the future. One of the usability measurement devices is the USE Questionnaire, which is divided into four main parameters, namely: Usability, Ease of Use, Ease of learning and User Satisfaction. Based on Usability parameters used on the USE Questionnaire, usability measurements are carried out in the Information system, mainly in the process of classrooms booking that are integrated with course scheduling information systems whose systems are improved to meet the desires of academic stakeholders, especially in Information Systems Department. The final result shows a number that is quite high in accordance with the numbers obtained from each parameter given. thus, all of these parameters have a very important meaning in evaluating using a USE Questionnaire.