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Hyperlipidemia is one of risk factor that can induce cardiac and vascular disease. Kersen leaf is believed lowering lipid profile because it is consist of flavonoids and tannins. The present study was a laboratorium experimental study with pre and post test control group design. The subjects were 30 male white rats (Rattus norvegicus), body weight approximately 200 grams, aged 3-4 months. Rats model were given high-fat diet and PTU for increasing lipid profile level. Rats divided into 5 groups with random sampling. The groups were negative control was not given any treatment, positive control was given simvastatin treatment, and (P1),(P2),(P3) group was given ethanol extract of kersen leaf 100, 200, and 400 mg/kgBB respectively. This study was held for 4 weeks. Lipid profile level was measured before and after therapy. The results showed that ethanol extract of kersen leaf (Muntingia calabura L.) at dose 400 mg / kgBB optimally can decrease LDL, total cholesterol and triglyceride level and can increase HDL level compared to standard therapy simvastatin. Overall, ethanol extract of kersen leaf (Muntingia calabura L.) is a potential folk medicine as antihyperlipidemi.