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Turmeric (Curcuma domestica Val) has a bioactive compound namely curcuminoid. It has many pharmacology effects such as anticancer, antidiabetic, antioxidant, hypolipidemic, anti-inflammatory, antimicrobial, antifertility, anti-venom, anti-coagulant, anti-HIV hepatoprotective, nephroprotective, and anticoagulant properties. To increase the economic value of Curcuma domestica Val, it is necessary to develop a hydrothermal extraction process of turmerics active compound. The advantages of hydrothermal extraction were inexpensive, abundant availability, high purity, non toxic, and easy to handle. This research aims to study the effect of operating condition : temperature (130-150oC), time (10-40 minutes) and solid:liquid ratio (1:10 and 1:12) on the bioactive compounds of turmeric extracted from hydrothermal extraction process. Generally, high extraction yield was obtained at higher extraction temperature (140 and 150oC). Under these conditions, with a lower solid : liquid ratio (1:10), high concentration of curcumin is produced. Further, a higher solid : liquid ratio will likely produce the opposite result, except when it operate at low extraction temperature. The high temperature of the pressurized liquid water can reduce the viscosity and surface tension of water so it will increase the diffusion rates and absorption. The higher the solid : liquid ratio, the greater the different concentration beetween interior and exterior cell, which promote the high efficiency of the diffusion process.