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Background: Disasters were conditions or events that threaten and disrupt the lives of people both caused by natural/non natural factors and human factors that cause victims environmental damage, property loss and psychological impact. Family was a major factor and the key to awareness in the face of disaster. Roles of Family were crucial in an effort to anticipate disaster situations. Aims: The aims of this research to analyze family behavior with awareness in the face of earthquake disaster in Tanjung village, Ende district. Methods: The research design was cross sectional with a large sample of 85 family heads. Data collection was done with interviews and observations. Analysis of the data used was bivariate analysis with a correlation test Spearman Rho. Results: The results showed that the knowledge average of respondents was 53.1 (± 50.7), the behavior average of respondents was 46.8 (± 50.7), and the awareness was 46.8 (± 50.7). There was relationship of knowledge and attitude to the awareness of the family in the face of disaster (OR 3.7; p = 0.043; 95%; CI 1.04-13.73); (OR 4.8; p = 0.04; 95%; CI 1.07-21.89). Conclusion: The family had less knowledge about earthquake disaster and a considerable behavior in the face of an earthquake disaster. The attitude and less knowledge of family affects family awareness in the face of disaster. It is necessary to have information about the preparation of tools and equipment in the face of earthquakes, periodically.