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Introduction : The present study was carried out to evaluate of antihyperglycemia properties of ethanolic leaves and seed extracts of neem (Azadirachta indica A. Juss) on glucose level and body weight on mice induced alloxan. Methods : This experimental research uses DDY mice from BPOM Jakarta. The extract was tested on diabetic DDY mice induced by alloxan at a dose of 120 mg/kg bw intraperitoneal. There were 9 groups of treatment and 3 replications. Doses used for treating these mice were A. Normal mice + Aquadest (control), B. Diabetic mice + Aquadest, C. Diabetic mice + Glibenclamide, D. Diabetic mice + leaves extract of neem with doses 0,25 g/kg bw, E. Diabetic mice + leaves extract of neem with doses 0,50 g/kg bw, F. Diabetic mice + leaves extract of neem with doses 1,00 g/kg bw, G. Diabetic mice + seeds extract of neem with doses 0,25 g/kg bw, H. Diabetic mice + seeds extract of neem with doses 0,50 g/kg bw, I. Diabetic mice + seeds extract of neem with doses 1,00 g/kg bw. All of treatments were given orally for 21 days. Glucose levels were calculated from the 1st week to 11th week and body weights were calculated from the 1st week to 7th week. The data were analyzed by ANOVA and LSD tests to compare groups A-I. Result : the research showed that the ethanol extract of leaves at a dose of 1,00 g/kg bw decreased glucose level of alloxan mice. There were highly significant differences (P<0,05) between group control and treatment. Based on the data analysis of body weight, there was no significant difference between group control and treatment. Conclusion : Ethanol extract of leaves and seeds extract of neem can be used to treat antihyperglycemia on mice induced alloxan.