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The researchs purpose was to measure the relationship of workload and motivation to employees performance and the effect of motivation on employees performance, workload on employees performance, workload and motivation on employees performance. This research was a quantitative approach with the methods used such as observation, interviews and questionnaires and data analysis was written using path analysis. Path analysis is a technique for analyzing causal relationships that occur in multiple regression. Relationship between workload and motivation on employees performance is 0.49. The effect of motivation on employees performance is significant at 30.02%, but the influence of workload on performance is non-significant at 5.48%. workload and motivation on employees performance is significant at 35.50%. Based on these results, the workload and motivation have a strong and significant relationship. Altough workload has a non-significant effect on employees performance partially, the workload and motivation have a significant effect on employees performance in medical manufacturing.