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Red betel leaf contains numerous phytochemical compounds that can be used as an antiinflammatory agent of rheumatoid arthritis. This research was conducted to determine the effect of red betel leaf extract on IL-1β and mole feet oedema thickness of RA model. Mice were modeled for RA by intraperitonally administered with 0.01 ml CFA and IFA on the near of left foot area with approximately 0.03 ml volume. The treatment was carried out for three weeks. Measurement of feet oedema thickness was done before and after treatment by using sliding, then the data were analyzed by using ANAKOVA. At the end of the treatment, the mice are empowered and dissected. Blood collected from the heart. IL-1β levels were measured using indirect ELISA technique and data were analyzed using single ANAVA. The results showed that red betel leaf extract of 200 mg/ml had a tendency to decrease IL-1β level in RA mice, whereas the thickness of oedema in mice of RA could be lowered by red leaf extract of 400 mg/ml. This results suggested that a decrease in IL-1β levels is also accompanied by a decrease in oedema thickness, due to an improved mechanism of the mice pane in RA mice.