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Diabetes mellitus has high prevalence which is influenced by several factors, that is lack of knowledge, physical activity and diet. The purpose of this research to look at the relationship between physical activity and knowledge in outpatients with type II diabetes mellitus at the Jets I Health Center, Bantul with Cross Section design with 71 patients as sampel. Data collection was prospective and interviewing using questionnaires of physical activity and knowledge. Data analysis using SPSS, descriptive test with chi square and the significant level of 0,05. There were no significant between knowledge and physical activity with p-value 0,536 > 0,05. There is no statistically significant difference between gender with knowledge and gender with physical activity. The p value in the knowledge group is 0.306 and in the physical activity group 0.273 .