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MCR is an organization under the PKBI Bandung Institute that has concerns in reproductive health education for high school teenagers. MCR has e-learning that contains materials about reproductive health. However, it is not accessible for visual impairment teenagers, for the example the picture in the e-learning cannot be read by screen reader software, and lack of reproductive health learning that specifically for the visual impairment teenagers causes the lack of comprehensive learning and lack of independent learning for visual impairment teenagers. So, the Android-based application of reproductive health learning was developed that can be accessed more easily by visual impairment teenagers through screen reader software. The application designed to implement multimodal interaction, that can become natural interaction involving several human senses in using applications that offer flexibility, efficiency and the use of a usable environment. The application allows the user to interact through several inputs such as touch, or gesture and get an output as a sound. In this study writer using a user-centered design method, so the design can be focused on the user. The result of the user interface model will be performed usability testing with the USE questionnaire method. Based on the usability testing result, It can be said has met the usability element accessible for the visual impairment teenagers.