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Information system security in the network becomes the most important thing to note, especially on a web application system, both organization and personal. Some ways that are used to provide a guarantee of data security is to verify the login to the web application system using One Time Password (OTP). However OTP sometimes still has a gap though OTP data only valid for one login session. This research develops information system security with OTP data encrypted with blowfish algorithm. The blowfish algorithm is divided into two main sub-algorithms namely the key expansion part and the data encryption-decryption section. OTP system design results developed blowfish algorithm data received and sent can be kept confidential.