Indonesia Conference Directory

Abstract The implementation of family planning (KB) programs by the government due to an increase in the rate of population growth using modern contraceptives can cause quite dangerous side effects. This study aims to determine the effect of pulutan leaf decoction (Urena lobata L.) on the length of the estrus cycle of mice (Mus musculus) Balb-C strain as a substitute for modern contraception. Mice were grouped into 6 treatment groups with 4 replications. P0 group as a control (0% concentration), P1 (5%), P2 (7,5%), P3 (10%), P4 (12,5%), and P5 (15%). The administration of pulutan leaf simplicia (Urena lobata L.) was carried out for 15 days orally (gavage). Determination of the estrus cycle was carried out by the mouse lavage technique every day for 15 days of treatment. The length of the estrus cycle is determined by calculating the length (days) between the estrus stage (initial treatment) until the next estrus stage (counted 4 stages). The results of the one way ANOVA test and the Duncan test revealed that there was an effect of pulutan leaves (Urena lobata L.) decoction on the estrus cycle length of the mice (Mus musculus) Balb / C strain (p <0.05). The administration of pulutan leaf simplicia can extend the estrus cycle of mice (Mus musculus) starting at a concentration of 7.5%. Abstract The implementation of family planning (KB) programs by the government due to an increase in the rate of population growth using modern contraceptives can cause quite dangerous side effects. This study aims to determine the effect of pulutan leaf decoction (Urena lobata L.) on the length of the estrus cycle of mice (Mus musculus) Balb-C strain as a substitute for modern contraception. Mice were grouped into 6 treatment groups with 4 replications. P0 group as a control (0% concentration), P1 (5%), P2 (7,5%), P3 (10%), P4 (12,5%), and P5 (15%). The administration of pulutan leaf simplicia (Urena lobata L.) was carried out for 15 days orally (gavage). Determination of the estrus cycle was carried out by the mouse lavage technique every day for 15 days of treatment. The length of the estrus cycle is determined by calculating the length (days) between the estrus stage (initial treatment) until the next estrus stage (counted 4 stages). The results of the one way ANOVA test and the Duncan test revealed that there was an effect of pulutan leaves (Urena lobata L.) decoction on the estrus cycle length of the mice (Mus musculus) Balb / C strain (p <0.05). The administration of pulutan leaf simplicia can extend the estrus cycle of mice (Mus musculus) starting at a concentration of 7.5%.