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Caspase-8 and TNFα are cellular molecules that play a role in apoptosis through the death receptor pathway. In connection with the study of toxification of formalin-containing foodfoodstuff and its detoxification using chlorophyllin, our research has previously proven that chlorophyllin supplementation was able to reduce the activation of Caspase-8 and the expression of TNFα which increases due to repeated exposure to formalin-containing foodstuffs. However, information about how significant the two molecules affect the initiation of apoptosis through the flow of caspase activation in the context of this toxicity is not clearly known. This study aims to determine the ratios of Caspase-8 and TNFα of liver cells of mice that experienced toxification of formalin and detoxification of chlorophyllin. Caspase-8 and TNFα of liver cells of mice that underwent the toxic-detoxification treatment were determined through immunohistochemical techniques. The ratio data of the two moleculs was analyzed descriptively and qualitatively. The results showed that the Caspase-8 and TNFα ratios varied with the toxicity-detoxification treatment, with a total ratio of 1.01.