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This study aims to enhance creative thinking skills of students using guided inquiry model trough of Stoichiometry. This study used quasi-experimental methods, with pretest-postest non equivalent control group design. Subjects of this study were biology students enrolled in basic chemistry, consist of 35 students in experimental class and 35 students in control class. Instrument in this study were essay test that involves 3 indicators of creative thinking skills (i.e. fluency, flexibility, and elaboration) and also student worksheets. The results showe that Stoichiometry using guided inquiry model have been enhance for creative thinking skills in high category for all indicators.