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Objective : To identify the dominant leadership style and to analyze the relationship between leadership style and nurse-s work motivation with the application of patient safety culture of the inpatient installation in the c class hospital of Bone regency. Methods : This research is a cross sectional study which involved 104 nurses in total sampling. Data were analyzed using the chi-square test (k x k). Result : The dominant leadership style of the inpatient nurse managers is transactional with a percentage of 69.2%. There was a significant relationship between leadership style (p<0.05) and nurse-s work motivation (p <0.05) with the application of patient safety culture, respectively. Conclusion : The transactional leadership has an impact on independent culture and the combination of extrinsic and intrinsic motivation has an impact on creating public service motivation which is good to build reporting and learning culture.