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Computational Study of Betatrophin/ANGPTL8 and HBV Interaction on Lipoprotein Lipase Activity in The Development of Hepatocellular Carcinoma Caused by Metabolic syndrome-related HBV infection
Hendra Susanto1*, I Kade Karisma Gita Ardana1, Melati Putri Pertiwi1, Elhah Nailul Khasna1, Abdul Ghofur1, Adeodatus Yuda Handaya2,3, Nia Lukita Ariani4

1) Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia
2) Faculty of Medicine, Universitas Gadjah Mada, Indonesia
3) Department of Digestive Surgery, Dr. Sardjito Hospital, Yogyakarta, Indonesia
4) Department of Nursing Sciences, Tribhuwana Tunggadewi University, Indonesia

*Corresponding Author-s email: hendrabio[at]um.ac.id


Abstract

Hepatocellular carcinoma is cancer, which is a significant problem in several countries in the world, one of which is Indonesia. The presence of hepatocellular carcinoma is often accompanied by the occurrence of the metabolic syndrome and infection of the HBV virus. Lipoprotein lipase (LPL) is an enzyme that is thought to be a key factor of metabolic syndrome occurrence and also HBV infection. This computational study aims to see the interaction between ANGPTL8 and HBV virus particles against LPL as a target. Our study shows that HBV and ANGPTL8 have different binding regions in the LPL enzyme so that they can bind simultaneously. Computationally HBV has stronger energy bonds than ANGPTL8. To sum up, this study can be the hallmark of another research to find out the role of LPL to the occurrence of Hepatocellular carcinoma by the binding of ANGPTL8 and HBV.

Keywords: Hepatocellular carcinoma, HBV, Betatrophin, Metabolic syndrome.

Topic: Bioinformatics

Link: https://ifory.id/abstract/C7X8JADzTmge

Conference: International Conference on Life Sciences and Technology (ICoLiST 2019)

Plain Format | Corresponding Author (Hendra Susanto)

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