Indonesia Conference Directory

Indonesia as one of the tropical countries has a high prevalence of dengue. Pathophysiology of dengue fever is through the role of the immune system, one of which is the role of cytokines. Interleukin 8 (IL8) is one of the pro-inflammatory cytokines produced by macrophage cells in the immune response. Several studies have linked interleukin 8 levels with dengue infection. The purpose of this study was to determine interleukin 8 levels in patients with dengue fever. The research design used was a cross-sectional study. Serum samples of 50 samples were collected and then examined for interleukin 8 levels using the ELISA method. The results of this study, more research subjects diagnosed with dengue fever as much as 90% (45 samples) and 10% (5 samples) dengue hemorrhagic fever. Through the Mann-Whitney test analysis, IL8 levels are expressed in the median (minimum-maximum). Levels of IL8 in dengue fever 19.76 (13,70-89,62) and 25,15 (15,74-25,87) in dengue hemorrhagic fever. The conclusion is that interleukin 8 levels were not statistically different between patients with dengue fever and dengue hemorrhagic fever.