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Fast Dissolving Film (FDF) have ability to releasing active pharmaceutical rapidly in oral mucosal with increasing bioavaibility of active pharmaceutical due to first passing hepatic metabolism. The aim of the research was formulated and evaluated FDF salbutamol sulfat with HPMC E15 polymer use solvent casting method. FDF salbutamol sulfat with variation of concentration HPMC E15 polymer was resulted film who flexible and semi transparent. The results of the evaluation of thickness, weight variation, folding endurance, surface pH, moisture loss, moisture uptake and disintegration time of film for all formulation was comply with a requested, except weight variation of F4, disintegration time of F1, F2, F3 and F4.