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Albumin is the main plasma protein responsible for regulating oncotic pressure as well as to transport many kinds of hormones, drugs and other substance throughout the body. The harmful impact of hypoalbuminemia which is met in various kind of diseases has led to the importance of rationality in albumin therapy to give effectiveness in normalizing albumin level. This study aims to determine the effectiveness of albumin therapy in various condition where hypoalbuminemia occurs. This study is an observational study. Data was gained retrospectively from medical records of patients with hypoalbuminemia. The study was able to obtain 168 data of patients from two private hospital in Yogyakarta from 2016-2018 which met the inclusion criteria. Determination of effectivenes of albumin therapy was conducted by T-test analysis comparing the albumin level before and after albumin therapy. The result of the study showed that patients given albumin therapy (intravenous) were mostly diagnosed with type 2 diabetes mellitus (16.67%). The mean increase in albumin level after therapy was 0.49 mg/dL. T-test analysis revealed a significant difference on albumin level before and after albumin therapy (p<0.05). Although there was a significant increase in albumin level, the clinical condition of the patient should be considered to determine the clinical effectiveness of albumin therapy.