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Argumentation plays an important role in the development of science which is not just finding and presenting facts, but building arguments and considering them, and debating various explanations about phenomena. The research aimed to capture the consistency of argument by students on socioscientific issues of cloning. Students have chosen purposively with the subject of 170 high school students from three high schools in Bandung City, West Java, Indonesia. This research uses a case study approach with a descriptive analysis to analyze student test results of argumentation. The consistency of argument consists of claims and reasons itself. The result shows the pattern of agreeing and disagree about cloning in 3 topics; 1) human, 2) animal for Qurban purposes, 3) extinct animals. The higher consistency showed disagree in topics 1&2 about 56,47% and consistency of reason for each topic are 1)religion 40%, 2) religion 57,6% and 3) science 83,5%. Then, the consistency of agreeing for all topics is 2,35% and disagree is 14,71%. This provides that, consistency in argumentation between topics of cloning is based on the context of phenomena, which is greatly influenced by science, religion, and social norms. It needs to be implemented to improved students argumentation in schools.