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Introduction according to the international Diabetes Federation in the case of diabetes in the world 2015 ; 382 million, 2016 ; 415 million, 2017 ; 425 million, prevalance Indonesia 6.9%, North Sumatera 5.3%, and Medan 2.3%. The Objective of the research was to analyze the hypertension and HDL which influenced the incidence of kidney failure complication in DM Type II patients at RSUD dr. Pirngadi, Medan. The sample inthe case group were 32 DM Type II patients with kidney failure complication, and in control group were 32 DM Type II patients without kidney failure complication. Each case of the subject was adjusted to the control according to age and sex. The data were analyzed by using chi square test, t-independent test, mann-whitney test, and multiple logistic regression analysis, the total of the 64 respondent. the result of multivariate analysis showed that hypertension OR ; 17.845, HDL OR; 7.049. The conclusion it was also found that the factor which the most dominant influence on the incidence of kidney failure complication in DM Type II patients was hypertension at the Population Attributable Risk of 91%. The Recommended was the DM Type II patients blood pressure should be controlled by applying dieting, physical activity, and taking medicines which are in line with DM Type II patients so that their glucose content and lipid profile which influence blood pressure and forestall the risk for kidney failure complication can be controlled.