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Syzygium samarangense (Blume) Merr. & Perry was the lipase inhibitor that capable of inhibiting lipid absorption, so it assumes have a potency to be antiobesity agent. The aim of this study was to investigated the antiobesity effect of ethanol extract and various fractions of jambu air samarang leaves. The ethanol extracts were prepared by maceration method while fractination process was carried out using liquid-liquid extraction method. This study was conducted on Wistar female rats induced by high carbohydrate food for 45 days and MSG (Monosodium Glutamate) subcutaneous injection 2 g/kg body weight for 5 consecutive days followed by 14 days treatment. Induction with high carbohydrate food was continue during the treatment. Results showed that MSG and high carbohydrate food could induce obesity. The ethanol extract at a dose of 50 mg/kg bw; n-hexane and ethyl acetate fraction have antiobesity effect by inhibit body weight gain significantly different to positive control group (p <0.05). The biggest activity was shown by the n-hexane fraction. The ethanol extract; n-hexane and ethyl acetate fraction of jambu air samarang leaves did not have laxative and anorexic effect, also could not decrease fat deposition in liver organ and abdominal fat tissue