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Background Systematic review (SR) is the highest evidence based resource in the health science area. It deals with a vast amount of data that each researcher is required to handle, therefore, managing the bibliography section in the SR project can be quite challenging. Aim The aim of this paper is to describe the management process of the bibliography collection and the data in a systematic research project using an open source software known as Zotero. Design/methodology/approach This study utilized a standalone Zotero obtained from www.zotero.orgto manage the bibliography section and other resources. This software also allowed for collaboration amongst researchers. The approach to the data and resources management is based on a previous SR study conducted by the first author and the data sample used in this study is based on current ongoing SR studies which implements four databases provided by the co-author whilst the supervision of the first author. Findings/Results Total result is2478 papers with an end process of 36 papers to be analyzed for the review. The process is divided into two main steps with a separate Zotero database for each step. The first database is specifically for collecting the search results from the four databases and removing duplicate papers. The end result of this first step is then exported into the second Zotero database, which becomes the main working area for the entire project. This two-step process is intended to keep the search results in the original state whilst keeping in mind that the main goal is to avoid losing the original data. Each collection is categorized since the first step of the SR in order to follow the multiple steps of SR process. This is to ensure that all researchers are able to keep track of the process and collaborate through the Zotero cloud storage. Practical Implication/Conclusion Using a bibliographic software is mandatory when working on SR, and the Zotero open source software has proven to be able to handle massive data in this type of research study.