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ABSTRACT Background: The disease of Diabetic if uncontrolled can cause fatal complications and severe effect such as coronary heart disease, kidney failure, blindness, infections due to ulcer until amputated the affected part ulcers and can lead to death. Approach to psychotherapy is expected can provide solutions to overcome the problems of handling diabetic comphrehensively in order to achieve more satisfying treatment. Objective: To determine the effect of guidance of pray book towards improvement coping mechanism among diabetes mellitus patients in Yogyakarta. Methods: This research conducted with experimental approach prepost with control design. Samples were taken by simple random sampling after selected that met the inclusion criteria such as composmentis, good communication and hearing, no complications. Obtained 60 sample of people and divided into two groups, the intervention group of 30 people and control group 30 people. Result: The coping mechanism before was only 12 (40%) in the adaptive category, increased after the intervention namely in the adaptive category of 21 people (70%), the Z value was 2.073 with p= 0.031. Social ability and social support are part of situation-oriented coping which is the ability to communicate and behave according to the norms prevailing in the community which includes supporting the fulfillment of information and emotional needs provided to individuals from the support of parents, family, friends and the environment surrounding diabetes mellitus Conclusion: Guidance of pray book to improve coping mechanism among diabetes mellitus patients at Yogyakarta. There is an effect of the accompanying prayer guide on the improvement of coping of diabetes mellitus patients