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Soaring drug prices and side effects for health have the effect of boosting food supplementation by utilizing natural resources. Increased consumption of phytochemicals that have antioxidant activity can suppress the onset of degenerative diseases. Therefore, it is necessary to prevent the improvement of food consumption patterns, one of which is natural antioxidants from papaya leaves. Proving the effect of giving jelly from extract papaya leaves to the level of SOD in healthy people. This research is an experimental study with a pre-post design randomized design involving 20 respondents consumption papaya leaves jelly within 20 days. Chlorophyll extraction was best found in extraction treatment with papaya leaf extract which had total chlorophyll content 11.29 mg/dL and antioxidant levels 52.13 mg/dL, taking into account the flavor and texture of jelly. Papaya leaf jelly has an effect on SOD levels (p = 0,000) with the meaning that it has a significant effect. Jelly from papaya leaf extraction 24.6 grams for 20 days gave a significant effect on increasing SOD levels in MDA levels in the blood.