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The implementation of package payment system for healthcare in Indonesia, or INA CBGs, as part of the National Health Security program, has been a focus of scrutinized studies. Indeed, for any private hospital, profit has been served as the main focus in supporting its operational. On the other hand, the prevalence of non-communicable diseases such as diabetes with the wide range of possible complications, has proven to be costly. Therefore, to maintain the sustainability of its service, private hospitals have to put the more efficient and effective cost management system into place, especially in the existence of INA CBGs. Objectives: objectives of this study is to predict the development of complication and the rate of medication cost among the member of JKN in one diabetes outpatient department in a hospital in Yogyakarta. Methods: The study using bivariate analysis to shows the correlation between complications and medication cost and medication, and using Multiple Discriminant Analysis to predict diabetes complications in future. Result: The results showed the complication rate has positively influenced the medication cost delivered by the hospital. Furthermore, the increased number of complications has led to the increased number of medication utilization which in turn has raised hospital-s operational cost: The Multiple Discriminant Analysis has successfully showed the prediction of diabetes complications with accuracy rate of prediction classification of 62.2%. . Therefore, it is regarded as essential to increase additional cost to cover the complication. Conclusion: The finding show that a more preventive measure program should be a key to prevent further complication which in turn would generate more profit.