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Effect of Nutmeg (Myristica fragrans) on p62 and LC3 Gene Expression in Cerebrum of Wistar Rat
Titing Nurhayati1,2, Mauiza Arkan Mahendra3,Yuni Susanti Pratiwi1,2, Ronny Lesmana1,2 Hanna Goenawan1,2, Keri Lestari4, Unang Supratman2,5

1Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
2Physiology Molecular Laboratory, Biological Activity Division, Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
3Undergraduate Program Medical Doctor, Faculty of Medicine, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
4Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
5Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.


Abstract

Aging leads to the progression of degenerative diseases. Degenerative disease is not curable in some extent but mostly preventable. Nutmeg has shown its effect to prevent sarcopenia-one of degenerative disease-by altering the process of autophagy thus increasing muscle mass. However, there is limited information about the effect of nutmeg on the process of autophagy in the brain especially cerebrum. Measuring the effect of nutmeg consumption on p62 and LC3 expression-which is the important biomarker of autophagy-in cerebrum is the objective of this research. This research is conducted by quantitative analytical methods using animal experiment. The rat was given nutmeg extract per oral. RNA are extracted from cerebrum samples to undergo PCR and Electrophoresis procedure to determine the level of p62 and LC3 gene expression in regards to the process of autophagy.

Keywords: Aging, degenerative disease, nutmeg, autophagy, cerebrum, p62, LC3.

Topic: Biomedical, Robotic and ICT engineering

Link: https://ifory.id/abstract/Jd9BQpKzPjNM

Conference: The 1st Bandung Applied Biomedical and Technology in Health Conference (BABTECH 2019)

Plain Format | Corresponding Author (Mauiza Arkan Mahendra)

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