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Morphology, Porosity, and Biodegradation of PVA/CS/PEG/HAp Nanofiber Composites as Scaffold in Bone Tissue Engineering
Hartatiek1), Yudyanto1), Nada Shofura F1), M. Nurhuda2), Masruroh2, a), and Djoko H Santjojo2, b)

1 Department of Physics, Universitas Negeri Malang, Jl. Semarang 5 Malang
2Department of Physics, Universitas Brawijaya, Jl. Veteran Malang


Abstract

The HAp scaffold has poor biodegradation. To increase biodegradation of HAp, it was composited with PVA, PEG and Chitosan polymers which had faster biodegradation properties. Nanofiber PVA/CS/PEG/HAp composites as scaffold in bone tissue engineering are prepared by electrospinning. The composition of HA varies 0, 2, 3, 4, 5 and 6% v. HAp was synthesized from natural deposits and characterized using X-Ray Diffraction (XRD) to obtain phase, crystallinity and crystal size. Surface morphology and porosity of nanofiber composites were characterized by SEM-EDX. Increasing the concentration of HAp can increase the average diameter of the nanofiber and reduce porosity. Composite biodegradation of PVA/CS/PEG/HAp was also evaluated. Biodegradation test was carried out by immersing the sample in SBF solution (Simulated Body Fluid) for 1-4 weeks and the fastest mass reduction occurred in HAp (0%) and decreased with increasing concentration of HAp. This nanofiber HAp/CS/PEG/HAp composite can be applied as a scaffold in bone tissue engineering.

Keywords: morphology, porosity. biodegradation, scaffold, nanofiber

Topic: Biomaterial Science

Link: https://ifory.id/abstract/JwUAx7rPE6ad

Conference: International Conference on Life Sciences and Technology (ICoLiST 2019)

Plain Format | Corresponding Author (Hartatiek Hartatiek)

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