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Patient safety is an important issue in hospital services. Appropriateness in health services, speed (timeliness), and freedom from danger and error (free from harm and error) are the three main elements of patient safety (patient safety). To realize hospital services that emphasize aspects of patient safety need to be built patient culture safety and patient safety attitudes from medical personnel, nurses and doctors to realize patient safety behavior. The purpose of this study is to model patient safety behavior which is influenced by patient culture safety and patient safety attitudes. This research was conducted at PKU Muhammadiyah Hospital Bantul with a sample of clinical practitioners, namely doctors and nurses. Data analysis was performed using PLS-SEM to analyze patient safety behavior models as well as the influence of patient safety culture and patient safety attitudes. The results show that the patient safety behavior model has a good level of goodness of fit. The culture of patient safety was found to have a positive influence on patient safety behavior. Patient safety attitude was also found to have a positive influence on patient safety behavior. These results confirm that patient safety behavior can be improved by enhancing patient safety culture and the attitude of patient safety from nurses and doctors in providing health services in hospitals.