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Chronic kidney disease and the treatment have an important part in shaping the QoL of patients receiving hemodialysis. As a result CKD affects the quality of life from the physical, psychological, social and environmental dimensions. A descriprtive analytic study was conducted in the hemodialysis unit of the RSUD Dr. Soegiri Lamongan. A total of 88 patients CKD with hemodialysis were studied. Patients QOL was rated by WHOQOL BREF questionnaires. The results showed that in the domain of quality of life, the low domain was physical with an average of 20 and the high domain was social with an average of 10. While most respondents with high quality of life as many as 78 people (88.6%) and a small respondents with medium quality of life as many as 10 people (11.4%). The results of this study can be concluded that most respondents have a high quality of life. However, the physical condition of CKD patients have significant problems. Thus, given the information by the hospital to overcome the physical disturbances that occur in CKD patients, so that his quality of life improved.