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Betatrophin Expression in Chronic Hepatitis C Patients: Does Contribute to Liver Injury-linked Metabolic Syndrome and Hepatocellular Carcinoma Development?
Hendra Susanto1, a), Nan-Shan Liou2, b), Chih-Hong Wang3, Bogi Pratomo4, Tinny Endang Hernowati5, Adeodatus Yuda Handaya7, Hani Susianti5, Moch. Bachtiar Budianto6, Abdul Gofur1, and Nia Lukita Ariani8

1Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia
2Department of Internal Medicine, National Taiwan University Hospital-Hsinchu Branch, Hsinchu, Taiwan-ROC
3Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan-ROC
4Department of Endocrinology, Saiful Anwar General Hospital, Malang, Indonesia
5Department of Clinical Pathology, Saiful Anwar General Hospital, Malang, Indonesia
6Division of Surgical Oncology, Department of Surgery, Saiful Anwar General Hospital, Malang
7Department of Surgery, Sardjito General Hospital, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
8Department of Nursing Science, Universitas Tribhuwana Tunggadewi Malang, Indonesia



a)Corresponding author: hendra.susanto.fmipa[at]um.ac.id
b)nanshan.liou[at]msa.hinet.net


Abstract

The epidemiologic evidence has been proved that chronic hepatitis C (CHC) infection may significantly contribute to the progression of hepatocellular carcinoma (HCV). Moreover, the prevalence of individual with CHC infection in Indonesia increased dramatically during the last decade. Importantly, there is no preliminary data, whether specific liver derived-hormone, betatrophin/ANGPTL-8/ can contribute to the early stage of HCC caused by HCV infection. The goal of this study was to provide a baseline data of betatrophin profile in subjects with CHC. Nineteen healthy control and fourteen CHC patients were considered as the samples and circulating betatrophin was measured by ELISA. Interestingly, the higher level of betatrophin was observed in an individual with CHC compared to placebo. Furthermore, the linear data was also found that the classical marker of liver injury, ALT significantly increased in the same patients. Based on this critical data, it is suggested that betatrophin may contribute to the early stages of HCC in connection to the gradual changes of HCV DNA and ALT level. Even though this finding could be a hallmark for the essential characteristic of betatrophin in CHC subjects progress to HCC, however, the future study with long-term monitoring in clinical observation of CHC patients is compulsory.

Keywords: betatrophin, chronic hepatitis C, metabolic syndrome, hepatocellualr carcinoma

Topic: Biomedical Science

Link: https://ifory.id/abstract/KMfeAQVhL6BW

Conference: International Conference on Life Sciences and Technology (ICoLiST 2019)

Plain Format | Corresponding Author (Hendra Susanto)

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