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Background: Plasma leakage is a problem that needs to be watched out for DHF patients which can lead to shock conditions and potentially cause death. Previous research on the use of methylprednisolone in adult DHF patients can significantly increase platelet counts but the evidence regarding the use of methylprednisolone in children DHF patients is still very limited. Objective : to determine the effect of giving methylprednisolone to clinical features, laboratory tests and length of stay in pediatric DHF patients at PKU Muhammadiyah Hospital, Bantul. Methods: The study design used RCT with a single blind. There were two groups, namely the intervention group was given methylprednisolone therapy and the control group was given a placebo. Bound variables measured were body temperature, trommbocytes, hematocrit and length of stay. Data analysis using the SPSS program. Result: There was no significant difference between groups on the number of platelet counts ,hematocrit and temperature variables where the p value was greater than 0.05. Whereas in the variable length of stay there are significant differences with the p value of 0.01 (p> 0.05). Conclusion: There were no significant differences in laboratory and clinical variables but there were significant differences in the variable length of stay.