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To survive in the 21st century requires a variety of skills. Achieving 21st century skills is conducted by updating the quality of learning, including in Biotechnology. Biotechnology is one of the subjects in Biology Education Study Program FKIP UNPAS Bandung, aims to provide as Biology teacher candidates that can apply, develop and disseminate science and technology professionally. The purpose of this study was to determine the learning process of biotechnology of students of Biology teacher candidates in the Biology Education Study Program. The method used was descriptive qualitative with a questionnaire consisting of 15 questions which are a mixture of questions in open and closed forms and also interviews. Amount 38 students and two lecturers were involved in this study. The results showed that the learning process in the Biology Education Study Program, FKIP UNPAS, still uses the classical method by teaching-centered learning system. Another finding that the enthusiasm of the teaching staff to develop themselves is very potential to encourage the improvement of the quality of the learning process in the near future. Evidently, although it is still centered on the instructors, lecturers have used a scientific approach, PPA models and power point media equipped with animated videos.