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The aim of this research was to evaluate how Understanding Nature of Science (NOS) play role to students Conceptual Understanding and Science Process Skills on Chemistry Classroom. This descriptive research was carried out by Ex-post Facto method at the Faculty of Mathematics and Science Education of IKIP Mataram. The research subjects were 75 students participating in the General Chemistry course for the academic year 2018-2019 that taken by the saturated sampling method. Data were collected by understanding NOS questionnaire, Concept Understanding Test, and Science Process Skills observation sheet. The data is described and analyzed by product moment correlation test and One Way Anova test for uncorrelated samples. The results showed that there was a significant and very strong correlation between Understanding NOS and Conceptual Understanding and between Understanding NOS and Science Process Skills. One Way Anova test result showed that there was difference on Students Conceptual Understanding and Science Processes Skills on different Understanding NOS