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Changes in the world are now entering the era of industrial revolution 4.0. The Ministry of Education and Culture responds quickly by preparing an appropriate learning curriculum so that students have the skills needed in this era. STEM-based learning is expected to be a solution in facing these challenges. This research aims to develop practical design STEM-based on carbohydrate learning through making paper from banana tree trunks. The use of banana tree trunks was chosen because of the high cellulose and hemicellulose content. The research method used is Research and Development consisting of defining stages, a preliminary study to find out the use of methods used in schools in general. Design stage is the making of learning devices in the form of Learning Implementation Plans and STEM-based student worksheets. Development stage is validated by experts and product trials to find out the feasibility of the practicum design that has been developed. The participants in this study were 25 students of class XII and chemistry teachers. Data was collected by using validation sheets, questionnaires, and observations. From the results of the validation, this research resulted in a feasible practicum design in paper making from banana tree trunks in carbohydrate learning.