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Background: Schizophrenia is one of ten diseases that contribute to the burden in the world according to the ranking of the World Health Organization and the incidence of schizophrenia afflicts 1.5 per 10,000 people where the diagnosis of schizophrenia will be faster enforced in men than women. Global schizophrenia affects around one percent of the worlds population, and about 1.2% or 3.2 million Americans get schizophrenia and around 1.5 million people in the world are affected schizophrenia. Family negative attitudes and family rejection against family members with mental disorder increased the incidence of recurrence in patients with mental disorder. The study aimed to determine the effect of supportive therapy on family attitudes and family rejection of family members with schizophrenia. The research design for this study was a quasi-experimental use cluster sampling. The study included (51 families (intervention group), 45 families (control group), Participants were asked to complete the family attitude scale and acceptance and rejection scale. The results showed there were significant changes in attitudes and rejection after given supportive therapy group (p value is 0.05). There is a significant difference in the change in the intervention group and the control (p-value is 0.05). The suggestion of this research is to apply supportive group therapy and family communities.