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This paper studies important factors that influence the physical workload of rice harvesters. Rice harvesting in Java, Indonesia, uses traditional and semi-mechanical harvests that require significant physical energy. Ergonomic Risk Factors (ERFs) are skeletal, muscle, and peripheral nerve disorders called Musculoskeletal Disorders (MSDs). Surveys and observations in Bantul Regency, Yogyakarta Province, many independent variables and one dependent variable is Cardiovascular Load (CVL), in multiple linear regression equations. Respondents were worker who harvested manual and semi-mechanical methods. Age and ambient temperature variables correlate strongly with CVL manual worker. CVL semi-mechanical harvest worker are strongly correlated with age and heart rate. By F test, manual worker workload, 94.5% is significantly influenced by variables of age, smoking habits, heart rate and ambient temperature. CVL semi-mechanical workers are only 91.1%. To avoid high CVL, the age factor of workers is a major consideration. MSDs occur in the upper and lower back for manual workers, semi-mechanical workers on the lower back and both hands. From the assessment of work posture in 4 elements of harvesting, transporting was the activity with the worst posture. Ergonomic interventions are needed to reduce ergonomic risks in transportation.