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Crude extract of mangosteen (GarciniaMangostana L) pericarp (CEMP) possess many biological and pharmacological activities. The aim of this study is to analyse the effect of CEMP consumption for 3 weeks on lipid peroxidation as shown by malondialdehyde (MDA) level in cigarette smoke exposed rats. Twenty five Wistar male rats were randomly divided into five groups, i.e.: a normal control group, an exposed cigarette control group and three treatment groups. The treatment groups either received 200; 400; and 600 mg CEMP/kg body weight (BW), respectively. The diets in the form of pellets were freely consumed (ad libitum) and were given for three weeks. Rats were exposed to cigarette smoke one time per day. Blood samples were taken on the last day for MDA analyses. The MDA level statically analysis by ANOVA test and following by post Hoc test .After 3 weeks treatment, the mean MDA levels between groups were significantly differences (P=0.000). On day 21th, the MDA levels of control group , exposure by cigarette smoke group and groups that supplemented with 0; 200; 400 and 600 mg CEMP / kg BW were 0.126 ± 0.02; 0.637 ± 0.04; 0.423 ± 0.03; 0.235 ± 0.03 and 0.136 ± 0.03 μg/mL, respectively.It is also interesting to point out the decrease of the lung morphological damage by CEMP treatment. These results indicate the beneficial effect of CEMP in the MDA level reducing on the rats that exposed by cigarette.