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The purpose of this study was to investigate the effects of an application of Virtual Reality in Cognitive Stimulation Program on cognitive function in the elderly with mild cognitive impairment (MCI) attending Geriatric Clinic at Nong Bua Lamphu Hospital, Thailand. Thirty elderly patients with MCI were included in this studied. The patients were screening with Barthel ADL index and IADL, MMSE Thai-2002 had high score than 22 with recall score below than 3/3 were inclusion criteria. This program was modifying from Cognitive Stimulation Program of Institute of Geriatric Medicine, Department of Medical Services, Ministry of Public Health. VR program developed by review literature, exposed to the application of program with 6-time cognitive stimulation program in 2 month included with VR technology was applied for 10 min per experiment. The result showed that, the cognitive function ability of the elderly group showed a statistically significant increase in MOCAs score after the exposure to the program (t = 8.900, p = .00) Conclusion Thus, an application of Virtual Reality in Cognitive Stimulation Program is an effective intervention for the elderly with MCI.