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The marine resources in Indramayu Regency have not been optimally utilized bythe community.Through learning at maritime vocational school,management of marine resources makes it possible to develop.The development of investigative practicum is development of practical learning design using 3D method which consists of 3 stages:define,design,develop.Development start from determining object of research,making practical investigation design,testing steps of investigative practical activities,testing the effect and effectiveness of investigative practicum design on students creativethinkingskill and lifeskills on quasyexperiment through Pretest Posttest Non-Equivalent Control Group Design.The research subject was determined by purposive sampling technique.Forty students from the 10th grade of APHP(FisheriesProductProcessingAgribusiness)studyprogram were selected to study biotechnology at SMK MitraMaritim.Data were collected using investigative worksheets, investigative observation sheets,creativethinkingskill instruments,lifeskill tests,questionnaires and interviews to explore students responses regarding investigative practicum.Results of this study are the developed design of investigative practicum thatwas testedwith an average difference test on ability to think creatively has a significance value of 0,000<0,05.Whereas lifeskills differed significantly at pretest-posttest.Pretest was 0.032<0.05,posttest was0.006<0.05. So that it can be concluded that investigativepracticum developed has an effect on creativethinkingskills but in lifeskills there are differences in beginning and ending skills in both classes.Effectiveness is shown from 80% of positive student responses to the application of investigative practical learning.