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IDENTIFICATION OF OFF-LABEL DRUG INDICATION USE IN PREGNANT WOMAN OF HOSPITAL
Pinasti Utami, Indriastuti Cahyaningsih, Widhy Hariyadi, Nurul Maziyyah, Bangunawati Rahajeng

School of Pharmacy
Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia


Abstract

Pregnant women have special characteristics in the use of drugs so requiring more attention in the administration. The use of drugs outside the information listed in the leaflet or "off-label" has a risk when used by special populations such as pregnant women. This study aimed to determine the identification of off-label drug use indicated for pregnant women in hospitals. This study conducted using descriptive observational design with cross-sectional approach. The sampling in this study used retrospective method on medical records of pregnant woman of Rumah Sakit Jogja. The medical record samples of 298 were taken using systematic random sampling technique from January to December 2016. The samples were then analyzed based on the information of drugs listed on the PIO Nas [National Drug Information Center] and related journals. The result showed that there were 2075 prescribed drugs in which there were 98 prescribed drugs (4,72%) categorized as off-label drug indication. The off-label drug indication use included misoprostol 79 (3,81%), dexamethasone 16 prescribed (0,77%), and ondansetron 3 prescribed (0,14%).

Keywords: off-label drug, indication, pregnant woman

Topic: International Symposium of Engineering, Technology, and Health Sciences

Link: https://ifory.id/abstract/PYMnk6FgwcVy

Conference: The 3rd International Conference on Sustainability and Innovation (ICoSI 2019)

Plain Format | Corresponding Author (Pinasti Utami)

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