Indonesia Conference Directory

The incidence of colon cancer in Indonesia reaches 12.8 per 100,000 adults and 9.5 deaths from all cancers. In the other side, colon cancer treatment has many side effects. Therefore it needs to develop colon cancer drugs combined with natural ingredients as co-chemotherapy to increase efficacy and reduce the side effects. One of them is roselle calyx (Hibiscus Sabdariffa L.) which contains the cyanidin-3-sambubioside (flavonoids) and derivatives which are thought to have the ability to inhibit the growth of cancer cells. This study aims to know activity of Rosella CalyxsEthanol Fraction (FEBR) based antioxidant, cytotoxic and molecular docking. The method used are antioxidant study, cytotoxic study with MTT Assay method and in silico study with molecular docking Autodock Vina method. Antioxidant activity of FEBR showed with IC50 value was 428 ug/ml. Cytotoxic potential of FEBR measured against WiDr cell line with IC50 value was 3483 ug/ml. The ability of cyanidin-3-sambubiosida to inhibit IKK and VEGF target proteins with affinity energy was -9.6 kcal / mol and -6.7 kcal / mol using docking molecular with Autodock Vina. Based on the results can be concluded that sianidin-3-sambubioside in FEBR is less potential to be developed as co-chemopreventive in colon cancer.