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Nowadays, one health awareness in the global value chain is increasing. Since, the threat of global occurrence of zoonotic diseases, and pathogens is higher due to global trade. Therefore, the trend of global food trade is driven by food security, sustainable agriculture, and healthy nutrition to foster the long-lasting well-being of the human population. However, food control and biosecurity as proactive and dynamic strategies were not having a clear aim between supporting producers or safeguarding consumers. These aims had a trade-off in policy impact resulting in possible lapses in food production and economic chaos. This paper aimed to describe the food control and biosecurity policy in the global value chain and its impact on global trade. We reviewed the literature on zoonotic diseases, and pathogens related to food production, biosecurity strategies and practices. Then, a comparative analysis was employed collated with the value chain governance to match its impact on supporting producers or safeguarding consumers. The results show that food control operational designs were inherently supported by biosecurity procedures. Moreover, the international regimes drove awareness, technical capacity and its impact on the policy dynamic in the global trade. The policy in Indonesia concerned more to support producers competitiveness in the global trade, while safeguarding consumers had less attention. This paper concluded that a more balanced policy is needed to implement food control and biosecurity in the global value chain.