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Nephrolithiasis is the most common kidney disease in Indonesia. One of the natural treatments for nephrolithiasis that is by using Sonchus arvensis plant. The purpose of this study was to determine the potential of Sonchus arvensis natural compounds in the nephrolithiasis treatment using reverse docking analysis. The reverse docking method is used to prove the potential of a compound through several databases and softwares. The results of reverse docking showed interaction of predictive compounds with target proteins, binding affinity, and predictive compounds- binding sites with target proteins. The predicted compounds results of reverse docking were tested for toxicity using Toxtree v2.6.13 software and bio oral potential with the Rule of Five Lipinski. The results showed that one of predicted compounds named Apigenin 7 glucoside has potential as an anti-nephrolithiasis-s candidate.