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Patient safety is a very important and fundamental thing in the daily activities of the hospital. This is one measure of the success of a hospital in carrying out its policies so that patients feel safe, comfortable and satisfied. This paper aims to identify determinant factors that influence the patient safety culture at the hospital. The literature search procedure to answer the problem is by searching the library online using the Pubmed search instrument, Cochrane Library, Google Scholar, Google and the relevant text book. The keywords used are "patient safety", "patient safety culture", "hospital", " determinant factors in patient safety culture ", and "patient safety dimensions" using limits, studies conducted at the hospital to hospital employees, publications English and Indonesian. With the search method, initially there were 30 articles, 22 of which met the criteria, published from 2005 until 2018. The results of the analysis from the literature review show that the patient safety culture is influenced by various determinant factors, including perceptions of management, work team support, work stress, job satisfaction towards the patient safety culture in the hospital. These factors were assessed by using some international standardized questionnaires such as the Safety Attitudes Questionnaire (SAQ) and questionnaire from the Agency for Healthcare Research and Quality (AHRQ). Leader factors in hospitals play an important role in the realization of a patient safety culture.