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One of therapy for chronic renal failures is hemodialysis. The problem that usually occurs in hemodialysis treatment is the patient therapy compliance. Patient compliance in undergoing therapy requires support from family members. The purpose of this study was to determine the correlation between the family support and the compliance on hemodialysis therapy in patients with chronic renal failure. This study employed a correlation analytic design with a cross-sectional approach. There were 136 respondents were recruited as the sample through convenience sampling technique. A self-constructed questionnaire was used in this study. The data were collected by using self-completed questionnaire. All respondents had completed the questionnaire. The data were analyzed by using Spearman-s rho statistical test. Among 136 respondents, 65,4% were male. The average age of the respondents was between 56 to 65 years old. There were 87.5% respondents had good family support. There were 88.2% respondents had good compliance. Statistical test results showed p-value <0.001 indicating there was a correlation between family support and compliance to patients underwent hemodialysis therapy. The patients family is expected to provide support for patients undergoing hemodialysis therapy. Therefore, patients will be obedient in undergoing a therapy program.