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Nanofiber through electrospinning process has been developed as a promising material for wound dressing due to its large porosity and high surface area. This characteristic of nanofiber provides a good gas permeability surrounding the wound which prevents a healing failure. The best wound dressing not only maintain a wound has a good gas permeability but also has an active agent to give an antibacterial and antiinflammation property. This research aims to combine a synthetic polymer and active agent, polyvinylpyrrolidone (PVP) and Binahong extract (BE), become nanofibrous material. The electrospinning process was conducted in two steps. The first step is to obtain the best condition PVP electrospinning with the voltage of 10, 12, 15, 17 kV, then combined PVP to 2%, 5%, 8% of BE in the second step. The first step shows the best operation condition in 12 kV so that to be used in different BE percentage. Based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the result indicates that reducing the BE composition will increase the antioxidant activity.