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Sarang banua plants are found in Simalungun, North Sumatra, Indonesia, which have been used by the community as traditional medicinal plants and is a type of Clerodendrum fragrans Vent Willd, including the family Verbenaceae. The study design was a completely randomized design (CRD) with five treatments namely 1% Na-CMC solution (K1, negative control), bovine serum antigen (K2), ethanol extract of sarang banua leaf 200 mg/kg BW (K3), ethanol extract of sarang banua leaf 200 mg/Kg BW with bovine serum antigen (K4) and ethanol extract of sarang banua leaf 150 mg/Kg BW with bovine serum antigen (K5). The results showed that administration of ethanol extract of sarang banua leaf (Clerodendrum fragrans Vent Willd) significantly affected serum globulin levels of rabbits (Oryctolagus cuniculus). The ethanol extract of sarang banua leaves 200 mg/kg BW with bovine serum antigen (K4) produced the highest serum globulin levels of rabbits (12.91 mg/mL).