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Based on the substances it contains, kaffir lime leaves (Citrus hystrix DC) are indicated to have efficacy in increasing female reproductive fertility. The purpose of this study was to examine the effect of kaffir lime leaf extract on the number of ovarian follicles of female white rats (Rattus norvegicus). This true-experimental research used three levels of extract concentration, i.e. 250 mg / kg, 500 mg / kg, and 750 mg / kg. Data from the study were analyzed using one-way ANOVA and continued with DMRT test. As a result, the administration of kaffir lime leaf extract had a significant effect on ovarian follicles number in white rats (p < 0.001). Treatment with a dose of 500 mg/kg and 750mg/kg did not have a significant difference in the number of primary, tertiary and de graff follicles, while the secondary follicles in the treatment of 750 mg/kg had a significantly higher number of other treatments. Therefore, kaffir lime leaf extract has the potential as herbal medicine for womens reproductive health.