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Particulate matters with the diameter less than 2.5 µm or PM2.5, have known to the health adverse. The developing of a measurement system of PM2.5 with a high precision has become a challenge in the last decade. We design the system using a NOVA SDS011 sensor to measure PM2.5 concentration. The problem is that the sensor has a capacity to measure particulate matter in the range of 0.3 to 10 µm, meanwhile we would like to design the measurement system of PM2.5 with the high precision. The other this is how to optimize the sensor. The factor influenced the sensor optimization has been investigated, such as the range of the particle measurement, a sample flow and sample compartment. The PM2.5 measurement system was calibrated using the 3443 Kanomax dust monitor. The result is that the system works well with the filter take into a role to the PM2.5 concentration measurement, and the sample flow and compartment that are the important factor to increase the precision of 20 %.