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STUDY OF EFFICACY LEMONGRASS (Cymbopogon citratus) EXTRACT AS LOWERING BLOOD CHOLESTEROL LEVEL AGENT ABSTRACT Muji Rahayu, Sistiyono hayuningpuji@gmail.com Lemongrass (Cymbopogon citratus) is a rich plant containing compounds called polyphenols, especially flavonoids. Lemongrass has been widely used in many counytries as antiinflamation, antibactaria, antifungal, antidiarhoea and as repellent to insect also proven to lower blood glucose. This study aims to determine the effect of the ethanol extract of lemongrass on blood lipids profile using 25 male albino rats Wistar strain, were devide into 5 groups, each group consisted of 5 rats, namely the control group (K), the drugs standard Simvastatin group (Sim) and the treatment group ES100, ES200 and ES400. All rats made hyperlipidemic by administration of diet high in fat and egg yolk for 14 days, then assayed lipid profile include total cholesterol, LDL, HDL and triglyceride (pre test). Furthermore, the group K were without treatment, S group were give drug standard simvastatin 0,18 mg/200g bwt, ES100, ES200 and ES400 group treated with ethanol extract of lemongrass respectively 100, 200 and 400 mg/kg bwt with sonde for 14 days. On the 15th days all rats were fasted and then have blood drawn through orbital venous and made serum and defined serum lipid profile (post test). The result showed the group of rat treated with ethanol extract decreased the levels of total cholesterol, LDL, and triglyceride as well as an increase in HDL cholesterol levels were significantly (p<0.05). This study showed the ethanol extract of lemongrass has lowering cholesterol levels and improve lipid profile in hyperlipidemic rats.